A roadmap for the development of alternative non-animal methods for systemic toxicity testing. ISSN X. Available under: doi: Pressures to move from traditional animal models to novel technologies arise from various concerns, including: the need to evaluate large numbers of previously untested chemicals and new products such as nanoparticles or cell therapiesthe limited predictivity of traditional tests for human health effects, duration and costs of current approaches, and animal welfare considerations.
The latter holds especially true in the context of the scheduled marketing ban on cosmetic ingredients tested for systemic toxicity. Based on a major analysis of the status of alternative methods Adler et al.
Five whitepapers were commissioned addressing toxicokinetics, skin sensitization, repeated-dose toxicity, carcinogenicity, and reproductive toxicity testing. An expert workshop of 35 participants from Europe and the US discussed and refined these whitepapers, which were subsequently compiled to form the present report.
By prioritizing the emily goldberg dating options to move the field forward, the expert group hopes to advance regulatory science.